The recent development of United States (US) foreign policy has been very dynamic, reflecting the complexity of global challenges. In an era marked by geopolitical tensions, government transitions, and a global pandemic, the United States faces a variety of important issues that influence foreign policy. One significant shift occurred in the Joe Biden administration’s return to multilateralism. Rejoining the Paris agreement on climate change and restoring relations with the World Health Organization (WHO) demonstrate the US’s commitment to collaborating on global issues. By reducing tensions with allies, Biden is focusing on diplomacy to confront challenges such as climate change and globalizing social injustice. Issues in the Asia-Pacific are also a major concern. The US Indo-Pacific strategy prioritizes the strength of alliances, especially through the Quadrilateral Security Dialogue (Quad) with Japan, India and Australia. This initiative is a response to China’s growing influence and is aimed at enhancing regional stability and security. On the other hand, US-China relations are increasingly complicated, with a focus on technological competition and trade, as well as human rights in Xinjiang and Hong Kong. Policy towards Russia also underwent a reaffirmation after Russia’s invasion of Ukraine. The US played a key role in providing military and humanitarian support to Ukraine, as well as imposing strict economic sanctions on Moscow. This reflects the US commitment to defend international rules and respond to military aggression. The Middle East remains a complex arena, with a revival of diplomacy through the normalization of relations between Israel and several Arab countries. The Abraham Accords initiative has created new opportunities for stability in the region. However, challenges such as Iran’s nuclear program and the conflicts in Yemen and Syria continue to color US foreign policy. In an economic context, the US continues to strive to rebuild global trade networks. Through supply chain reconstruction and a values-based approach, the US focuses on strengthening cooperation with allied countries while reducing dependence on countries that are considered threats, such as China. The current foreign policy of the United States cannot be separated from attention to human rights issues. This approach is reflected in more meaningful acts of public diplomacy, along with efforts to promote democracy in various parts of the world. This scale shows recognition of the important role of human rights in creating a more stable and peaceful world. Leadership in international organizations is also in focus, with Biden seeking to rebuild the power of US influence. Commitments to addressing global crises such as climate change, gender equality, and global health re-articulate US diplomatic prominence on the international stage. Changes in US foreign policy reflect a deeper understanding of the world’s complexities. In its position as a global power, adaptation and response to new challenges is key to ensuring stability and security. In this context, a multilateral approach and collaboration between countries is very crucial in formulating effective and sustainable policies.